- 英文名称
- 3-Hydroxy-N'-(2,4,5-trihydroxybenzylidene)-2-naphthohydrazide
- 分子式
- C18H14N2O5
- 分子量
- 338.31
- 中文别名
- Hydroxy-Dynasore; Dyngo®4a; DYNGO-4A; HYDROXY DYNASORE游离; 2-萘甲酸,3-羟基,2-[(2,4,5-三羟基苯基)亚甲基]酰肼; 3-羟基-N'-(2,4,5-三羟基亚苄基)-2-萘甲酰肼; Hydroxy-Dynasore; Dyngo-4a; 3-Hydroxynaphthalene-2-carboxylic acid-(2,4,5-trihydroxybenzylidene)-hydrazide; 3-Hydroxy-N'-[(E)-(2,4,5-trihydroxyphenyl)methylene]-2-naphthohydrazide; Dynamin Inhibitor IV; 2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(1E)-(2,4,5-trihydroxyphenyl)methylene]hydrazide; Hydroxy Dynasore; 3-hydroxy-N-[(E)-(2,4,5-trihydroxyphenyl)methylideneamino]naphthalene-2-carboxamide; 3-hydroxy-N'-[(2,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide; Dyngo-49; (E)-3-Hydroxy-N'-(2,4,5-trihydroxybenzylidene)-2-naphthohydrazide; 3-Hydroxy-2-naphthalenecarboxylic acid 2-[(2,4,5-trihydroxyphenyl)methylene]hydrazide; 3-Hydroxy-N′-[(2,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide; 3-Hydroxynaphthalene-2-carboxylic acid 2-[(2,4,5-trihydroxyphenyl)methylene]hydrazide
- 用途
- 作为改进的低细胞毒性dynamin抑制剂，体外研究中对重组Dynamin I和II的IC50分别为0.38 μM和2.3 μM，抑制网格蛋白介导的转铁蛋白内吞作用IC50为5.7 μM；体内腹腔注射30 mg/kg可在CD-1小鼠中保护肉毒杆菌毒素A诱导的麻痹。
