- 英文名称
- Ethyl 4-([1,1'-biphenyl]-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
- 分子式
- C27H29NO3
- 分子量
- 415.52
- 中文别名
- 试剂ITD-1; ITD 1; 4-[1,1'-联苯]-4-基-1,4,5,6,7,8-六氢-2,7,7-三甲基-5-氧代-3-喹啉羧酸乙酯; 化合物ITD1; ITD-1; Ethyl 2,7,7-trimethyl-5-oxo-4-(4-phenylphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxylate; ITD 1; ITD1; ethyl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate; IDT-1; ethyl 2,7,7-trimethyl-5-oxo-4-(4-phenylphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate; 4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester
- 用途
- 是有效的TGF-β抑制剂，不抑制TGFBR1或TGFBR的激酶活性，但能有效抑制TGFβ2诱导的效应因子SMAD2/3磷酸化，对Activin A影响甚微；可选择性增强未分化中胚层向心肌细胞分化，揭示TGFβ信号在控制多能心血管前体细胞向心肌细胞分化中的意外作用。
