- 英文名称
- Elenbecestat
- 分子式
- C19H18F3N5O2S
- 分子量
- 437.44
- 中文别名
- N-(3-((4aS,5R,7aS)-2-氨基-5-甲基-4a,5-二氢-4H-呋喃并[3,4-d][1,3]噻嗪-7a(7H)-基)-4-氟苯基)-5-(二氟甲基)吡嗪-2-甲酰胺; E2609; E-2609; E 2609; E-2609; E2609; N-[3-[(4aS,5R,7aS)-2-amino-5-methyl-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl]-4-fluorophenyl]-5-(difluoromethyl)pyrazine-2-carboxamide; 2-Pyrazinecarboxamide, N-(3-((4aS,5R,7aS)-2-amino-5,7-dihydro-5-methyl-4H-furo(3,4-d)(1,3)thiazin-7a(4ah)-yl)-4-fluorophenyl)-5-(difluoromethyl)-; N-(3-((4aS,5R,7aS)-2-Amino-5-methyl-4a,5-dihydro-4H-furo(3,4-d)(1,3)thiazin-7a(7H)-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide; N-(3-((4AS,5R,7aS)-2-amino-5-methyl-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide; elenbecestatum; N-(3-((4aS,5R,7aS)-2-amino-5-methyl-4,4a,5,7-tetrahydrofuro(3,4-d)(1,3)thiazin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide; N-{3-[(4aS,5R,7aS)-2-Amino-5-methyl-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]-4-fluorophenyl}-5-(difluoromethyl)pyrazine-2-carboxamide; N-(3-((4aS,5R,7aS)-2-amino-5-methyl-4H,4aH,5H,7H,7aH-furo(3,4-d)(1,3)thiazin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide
- 用途
- 生命科学领域，作为高效、口服活性且可透过CNS的BACE-1抑制剂，单次给药后能长效降低血浆中β-淀粉样蛋白水平，用于阿尔茨海默病相关研究。
