- 英文名称
- Echinocandin B
- 分子式
- C34H51N7O15
- 分子量
- 797.81
- 中文别名
- (2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-9-氨基-23-((1S,2S)-1,2-二羟基-2-(4-羟基苯基)乙基)-2,11,12,15-四羟基-6,20-双((R)-1-羟乙基)-16-甲基十六氢-1H-二吡咯并[2,1-c:2',1'-l][1,4,7,10,13,16]六氮杂环二十一烯-5,8,14,19,22,25(9H,25aH)-己酮; 棘球白素; 棘球白素 B; 棘白菌素B0; 阿尼芬净中间体; 1-((4R,5R)-4,5-二羟基-L-鸟氨酸)棘白菌素 B; (2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-9-Amino-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,12,15-tetrahydroxy-6,20-bis((R)-1-hydroxyethyl)-16-methylhexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosine-5,8,14,19,22,25(9H,25aH)-hexaone; 9-Amino-23-[1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,12,15-tetrahydroxy-6,20-bis(1-hydroxyethyl)-16-methylhexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosine-5,8,14,19,22,25(9H,25aH)-hexone; Echinocandin B nucleus; antibiotic a-30912a nucleus; Echinocandin B0; 1-[(4R,5R)-4,5-dihydroxy-L-ornithine]echinocandin b; Anidulafungin Impurity 9
- 用途
- 作为棘白菌素类药物的先导化合物，用于制备具有临床应用价值的抗真菌药物（如卡帕芬净、米卡芬净、阿尼芬净）；其作用机制为抑制真菌细胞壁β-(1,3)-D-葡聚糖合成，对唑类和两性霉素B耐药真菌（如曲霉、白色念珠菌）有强抗菌活性。
