- 英文名称
- 4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine
- 分子式
- C17H20F3N5S2
- 分子量
- 415.5
- 中文别名
- MI-2-2; 化合物MI-2-2; MI 0202; 化合物T28036; 4-(4-(5,5-二甲基-4,5-二氢噻唑-2-基)哌嗪-1-基)-6-(2,2,2-三氟乙基)噻吩并[2,3-D]嘧啶; 4-[4-(5,5-Dimethyl-4,5-dihydro-1,3-thiazol-2-yl)-1-piperazinyl]-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine; MI-2-2; 4-[4-(5,5-dimethyl-4H-1,3-thiazol-2-yl)piperazin-1-yl]-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine; Thieno[2,3-d]pyrimidine, 4-[4-(4,5-dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(2,2,2-trifluoroethyl)-; 4-(4-(5,5-dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin; 1-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)-4-[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]piperazine
- 用途
- 化学合成；MI-2-2是一种有效的menin-MLL抑制剂，以低纳摩尔亲和力(Kd=22 nM)与menin结合，能非常有效地破坏menin和MLL之间的二价蛋白质-蛋白质相互作用，在MLL白血病细胞中具有特异且显著的活性，包括抑制细胞增殖、下调Hoxa9表达和分化。
