- 英文名称
- 2-(4-(((7-(Diethylamino)-2,4-dioxochroman-3-ylidene)methyl)amino)phenyl)-N'-(1,2,3,4-tetrahydroacridin-9-yl)acetohydrazide
- 分子式
- C35H35N5O4
- 分子量
- 589.68
- 中文别名
- PE 154; 化合物PE 154; 化合物 T23131; (E)-2-(4-(((7-(二乙基氨基)-2,4-二氧代苯并二氢吡喃-3-亚基)甲基)氨基)苯基)-N'-(1,2,3,4-四氢吖啶-9-基)乙酰肼; PE 154; PE154; 2-(4-(((7-(diethylamino)-2,4-dioxo-2H-chromen-3(4H)-ylidene)methyl)amino)phenyl)-N'-1,2,3,4-tetrahydroacridin-9-ylacetohydrazide; 2-[4-[[7-(Diethylamino)-4-hydroxy-2-oxochromen-3-yl]methylideneamino]phenyl]-N'-(1,2,3,4-tetrahydroacridin-9-yl)acetohydrazide; (E)-2-(4-(((7-(Diethylamino)-2,4-dioxochroman-3-ylidene)methyl)amino)phenyl)-N'-(1,2,3,4-tetrahydroacridin-9-yl)acetohydrazide; 4-[[[7-(Diethylamino)-2,4-dioxo-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]-benzeneacetic acid 2-(1,2,3,4-tetrahydro-9-acridinyl)hydrazide; 2-(1,2,3,4-Tetrahydro-9-acridinyl)hydrazide-4-[[[7-(diethylamino)-2,4-dioxo-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]-benzeneacetic acid; Benzeneacetic acid, 4-[[[7-(diethylamino)-2,4-dioxo-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]-, 2-(1,2,3,4-tetrahydro-9-acridinyl)hydrazide; 2-[4-({[7-(diethylamino)-2,4-dioxo-3,4-dihydro-2H-1-benzopyran-3-ylidene]methyl}amino)phenyl]-N'-(1,2,3,4-tetrahydroacridin-9-yl)acetohydrazide
- 用途
- PE154 (Compound 13) 是 acetylcholinesterase (AChE) 和 butyrylcholinesterase (BChE) 的强效荧光抑制剂 (IC50 分别为 280 pM 和 16 nM)，可在组织化学分析中标记 β 淀粉样蛋白斑块。
