- 英文名称
- 1-[7,8-Dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxyethanone
- 分子式
- C26H29N7O2
- 分子量
- 471.55
- 中文别名
- AMG-925; AMG925; CDK4/FLT3双重抑制剂; 1-[7,8-二氢-2-[[9-(反式-4-甲基环己基)-9H-吡啶并[4',3':4,5]吡咯并[2,3-D]嘧啶-2-基]氨基]-1,6-萘啶-6(5H)-基]-2-羟基乙酮; 化合物AMG 925; AMG925; AMG-925; FLX925; FLX-925; FLX 925; 2-Hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone; Ethanone, 1-[7,8-dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxy-; 2-Hydroxy-1-[2-{[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino}-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]ethanone; 2-hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone; 2-hydroxy-1-[2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]ethanone
- 用途
- 简介
AMG 925是一种有效的，且口服具有生物活性的双重FLT3/CDK4抑制剂，IC50分别为1 nM 和 3 nM。
