- 英文名称
- 2-Cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide
- 分子式
- C24H24N6O2
- 分子量
- 428.49
- 中文别名
- (E)-2-氰基-3-(5-(1-环己基-1,6-二氢咪唑并[4,5-d]吡咯并[2,3-b]吡啶-2-基)呋喃-2-基)-N,N-二甲基丙烯酰胺; 化合物FM381; FM-381; FM 381; FM381; (2E)-2-Cyano-3-[5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-2-furyl]-N,N-dimethylacrylamide; (E)-2-Cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide; (E/Z)-2-Cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide; 2-Propenamide, 2-cyano-3-[5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-2-furanyl]-N,N-dimethyl-; 2-Propenamide,2-cyano-3-[5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-2-furanyl]-N,N-dimethyl-,(2E)-; (E)-2-cyano-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]-N,N-dimethylprop-2-enamide
- 用途
- 化学合成；作为JAK3的特异性抑制剂，具有可逆性，与JAK3共价结合，IC50为127 pM，对JAK1、JAK2、TYK2选择性分别为400倍、2700倍、3600倍，用于抑制JAK3介导的信号通路，如IL-2刺激的STAT5磷酸化。
