- 英文名称
- Cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
- 分子式
- C25H30N2O5
- 分子量
- 438.52
- 中文别名
- FLI-06; 1,4,5,6,7,8-六氢-2,7,7-三甲基-4-(4-硝基苯基)-5-氧代-3-喹啉羧酸环己基酯; FLI-06; 3-Quinolinecarboxylic acid, 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-, cyclohexyl ester; 1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester; Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate
- 用途
- 作为靶向Notch信号通路的新型抑制剂，EC50为2.3 μM；在过表达Notch绿色荧光蛋白的Hela细胞中抑制Notch的转运和处理，改变APP成熟模式并终止APPs释放，破坏高尔基复合体且抑制内质网转运前总蛋白分泌；在斑马鱼胚胎中50uM浓度可抑制内源性Notch信号
