- 英文名称
- Crosstide
- 分子式
- C48H77N17O17
- 分子量
- 1164.23
- 中文别名
- 模拟肽CROSSTIDE; (6S,9S,12S,15S,18S,21S,24S)-1-氨基-6-((S)-1-((S)-2-(2-氨基乙酰胺基)-5-胍基戊酰基)吡咯烷-2-甲酰胺基)-18-苄基-24-(2-羧基乙基)-9-((R)-1-羟基乙基)-12,15-双(羟甲基)-1-亚氨基-21-甲基-7,10,13,16,19,22,25-七氧代-2,8,11,14,17,20,23,26-八氮杂二十八N-28-酸; 化合物Crosstide; Glycine, glycyl-L-arginyl-L-prolyl-L-arginyl-L-threonyl-L-seryl-L-seryl-L-phenylalanyl-L-alanyl-L-a-glutaMyl-; Glycine, glycyl-L-arginyl-L-prolyl-L-arginyl-L-threonyl-L-seryl-L-seryl-L-phenylalanyl-L-alanyl-L-α-glutamyl-; (6S,9S,12S,15S,18S,21S,24S)-1-amino-6-((S)-1-((S)-2-(2-aminoacetamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-18-benzyl-24-(2-carboxyethyl)-9-((R)-1-hydroxyethyl)-12,15-bis(hydroxymethyl)-1-imino-21-methyl-7,10,13,16,19,22,25-heptaoxo-2,8,11,14,17,20,23,26-octaazaoctacosan-28-oic acid; (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[(2-aminoacetyl)amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-5-(carboxymethylamino)-5-oxopentanoic acid; H-Gly-Arg-Pro-Arg-Thr-Ser-Ser-Phe-Ala-Glu-Gly-OH; Glycyl-L-arginyl-L-prolyl-L-arginyl-L-threonyl-L-seryl-L-seryl-L-phenylalanyl-L-alanyl-L-alpha-glutamylglycine; (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[(2-aminoacetyl)amino]-5-guanidino-pentanoyl]pyrrolidine-2-carbonyl]amino]-5-guanidino-pentanoyl]amino]-3-hydroxy-butanoyl]amino]-3-hydroxy-propanoyl]amino]-3-hydroxy-propanoyl]amino]-3-phenyl-propanoyl]amino]propanoyl]amino]-5-(carboxymethylamino)-5-oxo-pentanoic acid; Glycyl-L-arginyl-L-prolyl-L-arginyl-L-threonyl-L-seryl-L-seryl-L-phenylalanyl-L-alanyl-L-α-glutamylglycine; Glycyl-N~5~-(diaminomethylidene)-L-ornithyl-L-prolyl-N~5~-(diaminomethylidene)-L-ornithyl-L-threonyl-L-seryl-L-seryl-L-phenylalanyl-L-alanyl-L-alpha-glutamylglycine
- 用途
- Crosstide 是一种糖原合成酶激酶α/β融合蛋白序列的模拟肽，是 Akt 的底物，用于体外研究16HBE14o− cells exposed to RV39时的激酶活性，可通过免疫印迹确认其丝氨酸磷酸化，磷酸化过程受PP2抑制但不受PP3抑制，野生型GST-AKT2对Crosstide有显著磷酸转移酶活性，突变体GST-AKT2T/E,S/D活性更高。
