- 英文名称
- alpha-Conotoxin ImI
- 分子式
- C52H78N20O15S4
- 分子量
- 1351.56
- 中文别名
- ALPHA-芋螺毒素 IM-I; Α-芋螺毒素IMI; 化合物alpha-Conotoxin imi; alpha-Ctx-imi; Gly-cys-cys-ser-asp-pro-arg-cys-ala-trp-arg-cys-NH2; Glycyl-cysteinyl-cysteinyl-seryl-asparginyl-prolyl-arginyl-cysteinyl-alanyl-tryptophyl-arginyl-cysteinamide; Glycyl-L-cysteinyl-L-cysteinyl-L-seryl-L-alpha-aspartyl-L-prolyl-N~5~-(diaminomethylidene)-L-ornithyl-L-cysteinyl-L-alanyl-L-tryptophyl-N~5~-(diaminomethylidene)-L-ornithyl-L-cysteinamide; H-Gly-Cys-Cys-Ser-Asp-Pro-Arg-Cys-Ala-Trp-Arg-Cys-NH2 (Cys2-Cys8, Cys3-Cys12); H-GLY-CYS-CYS-SER-ASP-PRO-ARG-CYS-ALA-TRP-ARG-CYS-NH2; A-conotoxin im I; a-Conotoxin IMI, Conus imperialis; α-conotoxin im i; L-Cysteinamide, glycyl-L-cysteinyl-L-cysteinyl-L-seryl-L-.alpha.-aspartyl-L-prolyl-L-arginyl-L-cysteinyl-L-alanyl-L-tryptophyl-L-arginyl-, cyclic (2-8),(3-12)-bis(disulfide); [(1R,4S,7S,13S,16S,19R,24R,27S,30S,33S,40R)-4,27-Bis(3-carbamimidamidopropyl)-24-carbamoyl-40-(glycylamino)-16-(hydroxymethyl)-30-(1H-indol-3-ylmethyl)-33-methyl-3,6,12,15,18,26,29,32,35,41-decaoxo-21,22,37,38-tetrathia-2,5,11,14,17,25,28,31,34,42-decaazatricyclo[17.16.7.07,11]dotetracont-13-yl]acetic acid
- 用途
- 化学合成；α-Conotoxin Im-I 是研究神经元 nAChR 的工具，具有毒性，能诱发啮齿动物癫痫发作，以最高的表观亲和力阻断 α7 尼古丁受体，对同体 α9 尼古丁受体的亲和力低 8 倍。
