- 英文名称
- Garcinol
- 分子式
- C38H50O6
- 分子量
- 602.8
- 中文别名
- (1R,5R,7R)-3-(3,4-二羟基苯甲酰基)-4-羟基-8,8-二甲基-5-((S)-5-甲基-2-(丙-1-烯-2-基)己-4-烯-1-基)-1,7-双(3-甲基丁-2-烯-1-基)双环[3.3.1]壬-3-烯-2,9-二酮; guttiferone F; guttiferone E; Camboginol; (1R,5R,7R)-3-(3,4-Dihydroxybenzoyl)-4-hydroxy-5-[(2S)-2-isopropenyl-5-methyl-4-hexen-1-yl]-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione; (1R,5R,7R)-3-(3,4-Dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methylbut-2-en-1-yl)-5-[(2S)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl]bicyclo[3.3.1]non-3-ene-2,9-dione; (1R,5R,7R)-3-(3,4-Dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-Bicyclo[3.3.1]non-3-ene-2,9-dione; (1R,3E,5R,7R)-3-[(3,4-dihydroxyphenyl)-hydroxy-methylidene]-8,8-dimethyl-1,7-bis(3-methylbut-2-enyl)-5-[(2S)-5-methyl-2-prop-1-en-2-yl-hex-4-enyl]bicyclo[3.3.1]nonane-2,4,9-trione; (1R,5R,7R)-3-(3,4-Dihydroxybenzyol)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]bicyclo[3.3.1]non-3-ene-2,9-dione; Bicyclo[3.3.1]non-3-ene-2,9-dione, 3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (1R,5R,7R)-
- 用途
- 化学合成;具有抗胆碱酯酶特性，对乙酰胆碱酯酶(AChE)和丁酰胆碱酯酶(BChE)的IC50分别为0.66μM和7.39μM；抑制组蛋白乙酰转移酶(HATs,IC50=7μM)和p300/CPB相关因子(PCAF,IC50=5μM)；具有抗炎和抗癌活性；可抑制CAL27和UMSCC1细胞增殖并诱导其凋亡，抑制IκBα的磷酸化和降解；体内可抑制肿瘤生长
