- 英文名称
- Euphorbia factor L1
- 分子式
- C32H40O8
- 分子量
- 552.66
- 中文别名
- 大戟素L1; Benzeneacetic acid, (1aR,2'S,4aR,6S,7S,7aR,8R,11aS)-4a,8-bis(acetyloxy)-1a,4a,5,6,7,7a,8,10,11,11a-decahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester; (E)-1,1,3,6-tetramethyl-4-oxo-7-(2-phenylacetoxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-4a,8-diyl diacetate; EUPATOROXIN,10-EPI; euphoria factor L1; 10-epi-Eupatoroxin; Benzeneacetic acid, (1aR,4aR,6S,7S,7aR,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester; (1aR,2Z,4aR,6S,7S,7aR,8R,9S,11aS)-4a,8-Diacetoxy-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate; Benzeneacetic acid, (1aR,2Z,4aR,6S,7S,7aR,8R,9S,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester; (1aR,4aR,6S,7S,7aR,8S,9R,11aS)-4a,8-Diacetoxy-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate
- 用途
- 作为中草药成分，具有抗肿瘤作用；用于含量测定、鉴定、药理实验等；具有抗癌、抗脂肪生成、抗破骨细胞生成和多重耐药调节作用；可降低 Bcl-2、PI3K、AKT 和 mTOR 蛋白和 mRNA 水平，上调 caspase-9 和 caspase-3 蛋白水平（对蛋白酶原无影响），诱导自噬（apoptosis）。
