- 英文名称
- Monactin
- 分子式
- C41H66O12
- 分子量
- 750.97
- 中文别名
- 化合物MONACTIN; Nonactin,5-demethyl-5-ethyl; 5-ethyl-2,11,14,20,23,29,32-heptamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone; Akd-1B; 5-deMethyl-5-ethylnonactin; AKD 1B; 4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone, 5-ethyl-2,11,14,20,23,29,32-heptamethyl-, (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-
- 用途
- Monactin是一种抗生素,也是单价阳离子(包括钾、钠和锂)的非选择性离子载体,具有抗增殖活性;体外对A2780卵巢癌细胞、A2058黑色素瘤细胞、H522-T1非小细胞肺癌细胞有强抗增殖活性;能抑制TCF/β-catenin转录活性;10μM浓度下可抑制粪肠球菌生长,且该抑制作用可通过添加过量K+逆转;是大鼠肝线粒体氧化磷酸化解偶联剂和ATP水解诱导剂。