7-[2-(环丙基甲氧基)-6-羟基苯基]-1,4-二氢-5-[(3S)-3-哌啶基]-2H-吡啶并[2,3-d][1,3]恶嗪盐酸盐; 化合物T14508; 7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride; Bay 65-1942 HCl salt; Bay 65-1942 (hydrochloride); Bay 65-1942 (HCl salt); Bay 65-1942 HCl; (S)-7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(piperidin-3-yl)-1H-pyrido[2,3-d][1,3]oxazin-2(4H)-one hydrochloride; KINK-1 hydrochloride; 2H-Pyrido[2,3-d][1,3]oxazin-2-one,7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-,Hydrochloride(1:1)
用途
Bay 65-1942盐酸盐是一种ATP竞争性的选择性IKKβ抑制剂；体外研究显示，缺血前给予Bay 65-1942可显著减小左心室梗死面积，降低梗死面积与危险区域面积的比值，并显著降低CK-MB水平；体内研究显示，MEK抑制剂（AZD6244）和IKK抑制剂（BAY 65-1942）在IC50浓度下使用时，对MYL-R细胞的活力有协同抑制作用，联合处理可增加caspase 3/7活性。
