- 英文名称
- DX-600
- 分子式
- C141H185N35O40S2.C2HF3O2
- 分子量
- 3188.37
- 中文别名
- ACE2特异性抑制剂多肽; 抑制剂Ac-Gly-Asp-Tyr-Ser-His-Cys-Ser-Pro-Leu-Arg-Tyr-Tyr-Pro-Trp-Trp-Lys-Cys-Thr-Tyr-Pro-Asp-Pro-Glu-Gly-Gly-Gly-NH2; Ac-Gly-Asp-Tyr-Ser-His-Cys-Ser-Pro-Leu-Arg-Tyr-Tyr-Pro-Trp-Trp-Lys-Cys-Thr-Tyr-Pro-Asp-Pro-Glu-Gly-Gly-Gly-NH2 (Disulfide bond); Glycinamide, N-acetylglycyl-L-α-aspartyl-L-tyrosyl-L-seryl-L-histidyl-L-cysteinyl-L-seryl-L-prolyl-L-leucyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-prolyl-L-tryptophyl-L-tryptophyl-L-lysyl-L-cysteinyl-L-threonyl-L-tyrosyl-L-prolyl-L-α-aspartyl-L-prolyl-L-α-glutamylglycylglycyl-, cyclic (6→17)-disulfide; (S)-5-((2-((2-((2-amino-2-oxoethyl)amino)-2-oxoethyl)amino)-2-oxoethyl)amino)-4-((S)-1-(((6S,9R,14R,17S,20S,23S,25aS,31S,34S,37S,40S,42aS)-20,23-bis((1H-indol-3-yl)methyl)-9-((S)-2-((S)-2-((S)-2-((S)-2-(2-acetamidoacetamido)-3-carboxypropanamido)-3-(4-hydroxyphenyl)propanamido)-3-hydroxypropanamido)-3-(1H-imidazol-5-yl)propanamido)-17-(4-aminobutyl)-37-(3-guanidinopropyl)-31,34-bis(4-hydroxybenzyl)-6-(hydroxymethyl)-40-isobutyl-5,8,16,19,22,25,30,33,36,39,42-undecaoxooctatriacontahydro-1H,13H-dipyrrolo[2,1-e1:2',1'-p][1,2]dithia[5,8,11,14,17,20,23,26,29,32,35]undecaazacyclooctatriacontine-14-carbonyl)-L-threonyl-L-tyrosyl-L-prolyl-L-aspartyl)pyrrolidine-2-carboxamido)-5-oxopentanoic acid
- 用途
- DX600是一种angiotensin-converting enzyme 2 (ACE2)的特异抑制剂，不会与ACE发生交叉反应
