- 英文名称
- 6-Methyl-1'-(2-(5-methyl-2-phenyloxazol-4-yl)ethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one
- 分子式
- C25H27N3O3
- 分子量
- 417.5
- 中文别名
- 6-甲基-1,1'-[2-(5-甲基-2-苯基-4-恶唑基)乙基]-螺[4H-3-1,1-苯并恶嗪-4,4'-哌啶]-2(1H)-酮; 6-甲基-1'-[2-(5-甲基-2-苯基-噁唑-4-基)乙基]-螺[4H-3,1-苯并噁嗪-4,4'-哌啶]-2(1H)-酮; 6-甲基-1'-(2-(5-甲基-2-苯基恶唑-4-基)乙基)螺[苯并[D][1,3]恶嗪-4,4'-哌啶]-2(1H)-酮; 化合物RS 504393; 6-甲基-1'-(2-(5-甲基-2-苯基恶唑-4-基)乙基)螺[苯并[D][1,3]恶嗪-4,4'-哌啶]-2(1H)-一; RS 504393; RS-504393; RS504393; Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 6-Methyl-1'-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethyl]-; 6-Methyl-1'-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidi; 6-Methyl-1'-(2-(5-methyl-2-phenyloxazol-4-yl)ethyl)spiro-[benzo[d][1,3]oxazine-4,4'-piperidin]-2(; 6-Methyl-1'-(2-(5-methyl-2-phenyloxazol-4-yl)ethyl)spiro-[benzo[d][1,3]oxazine-4,4'-piperidin]; 6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one; 6-methyl-1'-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one; 6-Methyl-1'-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethyl]spiro[3,1-benzoxazine-4,4'-piperidin]-2(1H)-one
- 用途
- 生命科学领域，作为选择性CCR2拮抗剂，作用于人重组CCR2和CCR1受体；体外研究中抑制MCP-1诱导的趋化性（IC50 330 nM），抑制变应原诱导的β-己糖胺酶释放，抑制MCP-1诱导的肥大细胞脱颗粒；体内研究中剂量依赖性阻断小鼠热痛觉过敏，抑制LPS诱导的白细胞增多、总蛋白含量升高及IL-1β、PAI-1 mRNA和蛋白表达，减轻肺水肿、蛋白液体积聚、多形核细胞浸润及支气管壁增厚，减少UUO模型中肾脏病理及间质纤维化。
