- 英文名称
- Aramchol
- 分子式
- C44H79NO5
- 分子量
- 702.1
- 中文别名
- (R)-4-((3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-二羟基-3-二十烷酰胺基-10,13-二甲基十六氢-1H-环戊二烯并[a]菲-17-基)戊酸; (4R)-4-[(3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-二羟基-3-(二十烷酰氨基)-10,13-二甲基十四氢-1H-环戊二烯并[a]菲-17-基]戊酸; (3β,5β,7α,12α)-7,12-二羟基-3-[(1-氧代二十烷基)氨基]胆甾烷-24-酸; 花生酰氨基胆烷酸; 胆固醇衍生物; (R)-4-((3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Dihydroxy-3-icosanamido-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid; (4R)-4-[(3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-3-(icosanoylamino)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid; R20-FBAC; (3β,5β,7α,12α)-7,12-Dihydroxy-3-(icosanoylamino)cholan-24-oic acid; (3beta)-Arachidylamido-7alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid; (3beta,5beta,7alpha,12alpha)-7,12-Dihydroxy-3-[(1-oxoeicosyl)amino]cholan-24-oic acid; C20-FABAC; Cholan-24-oic acid, 7,12-dihydroxy-3-[(1-oxoeicosyl)amino]-, (3β,5β,7α,12α)-
- 用途
- 生命科学领域应用；作为胆酸和花生酸的结合物，抑制硬脂酰辅酶A去饱和酶1（SCD1）活性，在非酒精性脂肪性肝病（NAFLD）和非酒精性脂肪性肝炎（NASH）中具有潜在应用潜能
