- 英文名称
- N-((3R,4S)-3-Hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)chroman-4-yl)-N-methylmethanesulfonamide
- 分子式
- C17H24F3NO5S
- 分子量
- 411.44
- 中文别名
- HMR-1556; 化合物 T15487; 化合物 HMR 1556; HMR 1556; HMR-1556; chromanol HMR1556; (+)-HMR-1556; Methanesulfonamide, N-((3R,4S)-3,4-dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl)-N-methyl-; N-[(3R,4S)-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)chroman-4-yl]-N-methylethanesulfonamide; (3R,4S)-(+)-N-(3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)chroman-4-yl)-N-methylmethanesulfonamide; (3r,4s)-(+)-N-[3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)chroman-4-yl]-N-methylmethanesulfonamide; N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmethanesulfonamide; N-[(3R,4S)-3-Hydroxy-2,2-dimethyl-6-(4,4,4-trifluoro-butoxy)-chroman-4-yl]-N-methyl-methanesulfonamide; N-[(3R,4S)-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)chroman-4-yl]-N-methyl-methanesulfonamide
- 用途
- HMR 1556是色氨醇衍生物，是一种有效的IKs阻滞剂，在犬和豚鼠的左心室肌细胞中的IC50值分别为10.5 nM、34 nM；体外研究显示其在犬左心室肌细胞中对Ito、ICa,L和IKr的抑制IC50分别为33.9 μM、27.5 μM、12.6 μM，应用于生命科学领域的生物活性研究。
