- 英文名称
- BIRT-377
- 分子式
- C18H15BrCl2N2O2
- 分子量
- 442.13
- 中文别名
- (5R)-5-[(4-溴苯基)甲基]-3-(3,5-二氯苯基)-1,5-二甲基-2,4-咪唑烷二酮; BIRT 377; 化合物 T23796; 化合物BIRT-377; BIRT 377; (5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione; (5R)-5-(4-Bromobenzyl)-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione; (5R)-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-1,5-dimethylimidazolidine-2,4-dione; (5R)-5-[(4-bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethylimidazolidine-2,4-dione; (R)-5-(4-bromophenyl)-3-(3,5-dichlorophenyl)-1,5-dimethylimidazolidine-2,4-dione; birt377; (R)-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-1,5-dimethylimidazolidine-2,4-dione; (R)-5-(4-Bromo-benzyl)-3-(3,5-dichloro-phenyl)-1,5-dimethyl-imidazolidine-2,4-dione; 2,4-Imidazolidinedione, 5-[(4-bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-, (5R)-
- 用途
- BIRT 377是一种能有效抑制细胞间粘附分子-1 (ICAM-1)与淋巴细胞功能相关抗原-1 (LFA-1) 相互作用的抑制剂，具有口服生物利用性，Ki为25.8 nM。BIRT 377也能在体内抑制IL-2的产生。BIRT 377可用于炎症与免疫紊乱的研究。
