- 英文名称
- Deoxyelephantopin
- 分子式
- C19H20O6
- 分子量
- 344.36
- 中文别名
- 脱氧地胆草素; 去氧地胆草内酯; 去氧苦地胆苦素; (3aR,4S,9R,11E,12aR)-11-甲基-3-亚甲基-2,7-二氧代-2,3,3a,4,5,9,10,12a-八氢-7H-6,9-(甲桥)呋喃并[2,3-f][1]氧杂环十一烯-4-基 甲基丙烯酸酯; Elephantopus carolinianus compd. B; (3S,4R,8R,9Z,12R)-10-Methyl-5-methylene-6,14-dioxo-7,13-dioxatricyclo[10.2.1.0]pentadeca-1(15),9-dien-3-yl methacrylate; 2-Propenoic acid, 2-methyl-, (3aR,4S,9R,11Z,12aR)-2,3,3a,4,5,9,10,12a-octahydro-11-methyl-3-methylene-2,7-dioxo-7H-9,6-methenofuro[2,3-f]oxacycloundecin-4-yl ester; 2-Methylpropenoic acid (3aR,4S,9R,11E,12aR)-2,3,3a,4,5,9,10,12a-octahydro-2,7-dioxo-11-methyl-3-methylene-7H-9,6-methenofuro[2,3-f]oxacycloundecin-4-yl ester; 2-Propenoic acid,2-methyl-,(3aR,4S,9R,11E,12aR)-2,3,3a,4,5,9,10,12a-octahydro-11-methyl-3-methylene-2,7-dioxo-7H-9,6-methenofuro[2,3-f]oxacycloundecin-4-ylester; (3aR,4S,9R,11E,12aR)-11-Methyl-3-methylene-2,7-dioxo-2,3,3a,4,5,9,10,12a-octahydro-7H-6,9-(metheno)furo[2,3-f][1]oxacycloundecin-4-yl methacrylate
- 用途
- 中草药成分，具有显著的抗癌活性；可广泛用于癌症方面的研究，抑制NF-κB、MAPK、PI3K/Akt和β-catenin信号传导；抑制HCT 116（结直肠）、K562（慢性髓系白血病）、KB（口腔）、T47D（乳腺）癌细胞系生长，IC50分别为7.46、4.02、3.35、1.86 μg/mL；增加p53、p-JNK、p-p38表达，降低p-STAT3、p-mTOR表达；下调MMP-2、MMP-9、uPA、uPAR mRNA水平。
