- 英文名称
- Nimbolide
- 分子式
- C27H30O7
- 分子量
- 466.52
- 中文别名
- 宁波利特; 奈博德; (2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-(3-呋喃基)-2a,5a,6,6a,8,9,9a,10a,10b,10c-十氢-2a,5a,6a,7-四甲基-2,5-二氧代-2H,5H-环戊并[d']萘并[1,8-bc:2,3-b']二呋喃-6-乙酸甲酯; Methyl [8-(3-furyl)-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[b]furo[2',3',4':4,5]naphtho[2,3-d]furan-6-yl]acetate; 2H,5H-Cyclopenta[d]naphtho[2,3-b:1,8-b'c']difuran-6-acetic acid, 8-(3-furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-, methyl ester; (17R)-7α,15β:21,23-Diepoxy-6α-hydroxy-4,8-dimethyl-1-oxo-11-methoxycarbonyl-18,24-dinor-11,12-seco-5α-chola-2,13,20,22-tetrene-4α-carboxylic acid γ-lactone; methyl [(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-furan-3-yl-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[d]naphtho[2,3-b:1,8-b''c'']difuran-6-yl]acetate
- 用途
- Nimbolide是源自Azadirachta indica L叶和花的三萜化合物，通过抑制NF-κB诱导肿瘤细胞凋亡，抑制CDK4/CDK6激酶活性，抑制NF-κB、Wnt、PI3K-Akt、MAPK和JAK-STAT信号通路；在印楝树可食用部分存在，对人结肠癌细胞HT-29有生长抑制作用，2.5-10μM浓度下可导致中度至非常强的生长抑制。
