- 英文名称
- Saperconazole
- 分子式
- C35H38F2N8O4
- 分子量
- 672.72
- 中文别名
- 沙柏康唑; 萨波康唑; 4-[4-[4-[4-[[2-(2,4-二氟苯基)-2-(1H-1,2,4-三唑-1-基甲基)-1,3-二氧戊环-4-基]甲氧基]苯基]-1-哌嗪基]苯基]-2,4-二氢-2-(1-甲基丙基)-3H-1,2,4-三唑-3-酮; saperconazole; Saperconazol; Saperconazolum; R66905; 2-(1H-1,2,4-Triazol-1-ylmethyl)-2-(2,4-difluorophenyl)-4-[[4-[4-[4-[[2-(1-methylpropyl)-2,3-dihydro-3-oxo-4H-1,2,4-triazol]-4-yl]phenyl]piperazin-1-yl]phenoxy]methyl]-1,3-dioxolane; 2-sec-Butyl-4-[4-[4-[4-[[2-(1H-1,2,4-triazole-1-ylmethyl)-2-(2,4-difluorophenyl)-1,3-dioxolane-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-3H-1,2,4-triazole-3-one; R-66905; (+-)-1-sec-Butyl-4-(p-(4-(p-(((2R*,4S*)-2-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-one; 3H-1,2,4-Triazol-3-one, 4-(4-(4-(4-((2-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-; 2-(Butan-2-yl)-4-(4-{4-[4-({(2R,4S)-2-(2,4-difluorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]-1,3-dioxolan-4-yl}methoxy)phenyl]piperazin-1-yl}phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
- 用途
- 作为广谱抗真菌药，具有很强的抗曲霉菌活性，MIC90值为0.19 mg/L，体外研究显示1 μg/mL时对除一株黑曲霉外的所有菌株活性完全，80%菌株在0.1 μg/mL时无生长（85%烟曲霉）且持续14天；体内研究中，感染烟曲霉的对照鸽在2-5天内死亡，5或10 mg/kg沙康唑给药后存活率分别达92%或100%，器官培养阴性且无药物相关副作用。
