Ginsenoside Rc is a major ginseng saponin, enhances GABA_A-mediated ion channel currents, inhibits TNF-α and IL-1β expression, exerts anti-inflammatory effects by suppressing specific signaling pathways, and regulates proinflammatory cytokine expression. It is used as a chromatographic standard, in traditional Chinese medicine, and in pharmaceutical health products for anti-fatigue, anti-aging, and brain health, and has anti-tumor growth properties.
- 生物活性
Temocapril HCl (CS-622)是Temocapril的盐酸盐形式，是一种长效的血管紧张素转换酶（ACE）抑制剂，用于治疗高血压。
- 靶点
Target
Value
ACE
- 体外研究
Temocapril hydrochloride is a prodrug of the ACE inhibitor, Temocaprilat. Temocapril hydrochloride can be readily uptaken via the human small intestine, and then be converted to its active metabolite (temocaprilat) by CES1 in the liver.
- 体内研究
Temocapril hydrochloride (30 mg/kg; p.o.; daily; for 4 weeks) suppresses Angiotensin I-induced hypertension, plasma and renal ACE activity, but fails to reduce the level of Ang II in the kidney.
Animal Model:
Male Sprague Dawley rats
Dosage:
30 mg/kg
Administration:
Oral administration, daily, for 4 weeks
Result:
Suppressed the blood pressure elevation induced by Ang I.
