- 英文名称
- Tautomycin
- 分子式
- C41H66O13
- 分子量
- 766.96
- 中文别名
- 化合物 T13095; Tautomycin from Streptomyces spiroverticillatus; tautomycin; 3-Furanpropanoic acid, 2,5-dihydro-β-hydroxy-4-methyl-2,5-dioxo-, (1R,2S,3R,6S,7S,10R)-10-[(2S,3S,6R,8S,9R)-3,9-dimethyl-8-[(3S)-3-methyl-4-oxopentyl]-1,7-dioxaspiro[5.5]undec-2-yl]-3,7-dihydroxy-2-methoxy-6-methyl-1-(1-methylethyl)-5-oxoundecyl ester, (βR)-; ((1R,2R,3R,6S,7S,10R)-10-((2S,3S,6R,8S,9R)-3,9-dimethyl-8-((3S)-3-methyl-4-oxo-pentyl)-1,7-dioxaspiro(5.5)undecan-2-yl)-3,7-dihydroxy-1-isopropyl-2-methoxy-6-methyl-5-oxo-undecyl) (3R)-3-hydroxy-3-(4-methyl-2,5-dioxo-3-furyl)propanoate; [(1R,2R,3R,6S,7S,10R)-10-[(2S,3S,6R,8S,9R)-3,9-dimethyl-8-[(3S)-3-methyl-4-oxo-pentyl]-1,7-dioxaspiro[5.5]undecan-2-yl]-3,7-dihydroxy-1-isopropyl-2-methoxy-6-methyl-5-oxo-undecyl] (3R)-3-hydroxy-3-(4-methyl-2,5-dioxo-3-furyl)propanoate; ((3R,4R,5R,8S,9S,12R)-12-((2S,3S,6R,8S,9R)-3,9-dimethyl-8-((3S)-3-methyl-4-oxopentyl)-1,7-dioxaspiro(5.5)undecan-2-yl)-5,9-dihydroxy-4-methoxy-2,8-dimethyl-7-oxotridecan-3-yl) (3R)-3-hydroxy-3-(4-methyl-2,5-dioxofuran-3-yl)propanoate
- 用途
- 作为蛋白磷酸酶1和2A的有效特异性抑制剂，在无Ca2+情况下诱导平滑肌收缩；体外研究显示对人甲状腺髓样癌细胞（MTC）生长呈剂量依赖性抑制，且降低NE标志物ASCL1和CgA表达。
