- 英文名称
- Hederacolchiside A1
- 分子式
- C47H76O16
- 分子量
- 897.1
- 中文别名
- 革叶常春藤皂苷A1; 竹节香附皂苷R13; 齐墩果酸-3-O-α-L鼠李吡喃糖基-(1→2)[β-D-葡萄吡喃糖基-(1→4)]-α-L-吡喃阿拉伯糖苷; 黑海常春藤皂苷A1; 齐墩果酸-3-O-β-D-吡喃鼠李糖基-(1→2)-[β-D-吡喃葡萄糖基-(1→4)]-α-L-吡喃阿拉伯糖苷; 齐墩果酸-3-O-β-D-吡喃鼠李糖基-(1→2)-β-D-吡喃葡萄糖基-(1→4)-α-L-吡喃阿拉伯糖苷; (4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-(((2S,3R,4S,5S)-4-羟基-5-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-3-(((2S,3R,4R,5R,6S)-3,4,5-三羟基-6-甲基四氢-2H-吡喃-2-基)氧基)四氢-2H-吡喃-2-基)氧基)-2,2,6a,6b,9,9,12a-七甲基-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-十八氢苉-4a(2H)-羧酸; (4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-(((2S,3R,4S,5S)-4-Hydroxy-5-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid; (3β,5ξ,18α)-3-{[6-Deoxy-α-L-mannopyranosyl-(1->2)-[β-D-glucopyranosyl-(1->4)]-α-L-arabinopyranosyl]oxy}olean-12-en-28-oic acid; Pulchinenoside B7; raddeanoside R14; oleanolic acid 3-O-{O-alpha-L-rhamnopyranosyl-(1->2)-O-[beta-D-glucopyranosyl-(1->4)]-alpha-L-arabinopyranoside}; oleanolic acid-3-O-alpha-L-rhamnopyranosyl-(1->2)-[beta-D-glucopyranosyl-(1->4)]-alpha-L-arabinopyranoside; Raddeanoside R13; Olean-12-en-28-oicacid, 3-[(O-6-deoxy-a-L-mannopyranosyl-(12)-O-[b-D-glucopyranosyl-(14)]-a-L-arabinopyranosyl)oxy]-, (3b)-; Oleanolic acid-3-O-β-D-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)-]-α-L-arabinopyranoside; Olean-12-en-28-oic acid, 3-[(O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosyl)oxy]-, (3β)-; Oleanolic acid-3-O-β-D-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)--α-L-arabinopyranoside
- 用途
- 生命科学；中草药成分；生物活性（调节 PI3K/Akt/mTOR 信号通路诱导凋亡，抑制肿瘤细胞增殖；抗血吸虫病活性）；靶点（PI3K、Akt、mTOR）；体外研究（降低线粒体膜电位和 Bcl-2 蛋白水平，提高 cleaved caspase-3；抑制 PI3K、Akt、mTOR 磷酸化）；体内研究（3.0-6.0 mg/kg ip 抑制 H22 异种移植模型肿瘤重量；3.25-15.0 mg/kg ig 抑制 MCF-7 异种移植模型肿瘤重量）
