- 英文名称
- Dehydrocorydaline chloride
- 分子式
- C22H24ClNO4
- 分子量
- 401.88
- 中文别名
- 盐酸脱氢紫堇碱; 盐酸去氢延胡索碱; 盐酸去氢紫堇碱; 盐酸脱氢延胡索碱; 盐酸脱氢紫堇硷; 2,3,9,10-Tetramethoxy-13-methyl-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium chloride; 13-Methylpalmatine chloride; 2,3,9,10-tetramethoxy-13-methyl-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium chloride; Dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-13-methyl-, chloride (1:1); Dehydrocorydaline (chloride)
- 用途
- Dehydrocorydaline chloride (13-Methylpalmatine chloride) is a bioactive alkaloid from Corydalis yanhusuo. It regulates Bax/Bcl-2 expression, activates caspases-7/-8, inactivates PARP, enhances p38 MAPK activation, and has anti-inflammatory, anti-cancer, and potent antimalarial effects (IC50=38 nM for P. falciparum 3D7). In vitro, it promotes muscle differentiation and inhibits MCF-7 proliferation via apoptosis. In vivo, it shows dose-dependent antinociceptive effects in mice.
