- 英文名称
- H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH
- 分子式
- C58H71N11O15S2
- 分子量
- 1226.38
- 中文别名
- TNF-Α拮抗剂; ((4R,7S,10S,13S,16S,19S,22R)-19-((1H-Indol-3-yl)methyl)-22-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-13-(3-amino-3-oxopropyl)-10-(4-hydroxybenzyl)-16-(hydroxymethyl)-7-isobutyl-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexaazacyclotricosane-4-carbonyl)-L-tyrosine; TNF-α Antagonist; WP9QY; TUMOR NECROSIS FACTOR-ALPHA ANTAGONIST; TNF-ALPHA ANTAGONIST; H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH, (Disulfide bond); WP9QY, W9, YCWSQYLCY; (2S)-2-[[(4R,7S,10S,13S,16S,19S,22R)-22-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-13-(3-amino-3-oxopropyl)-16-(hydroxymethyl)-10-[(4-hydroxyphenyl)methyl]-19-(1H-indol-3-ylmethyl)-7-(2-methylpropyl)-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexazacyclotricosane-4-carbonyl]amino]-3-(4-hydroxyphenyl)propanoic acid; L-Tyrosyl-L-cysteinyl-L-tryptophyl-L-seryl-L-glutaminyl-L-tyrosyl-L-leucyl-L-cysteinyl-L-tyrosine cyclic (2-8)-disulfide
- 用途
- 化学合成；作为TNF-α拮抗剂，模拟TNF受体I上最关键的肿瘤坏死因子(TNF)识别环，防止TNF与其受体相互作用，是开发小分子抑制剂的有用模板，可预防类风湿性关节炎中的炎症性骨破坏和全身性骨丢失。
