- 英文名称
- (3aS)-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide
- 分子式
- C10H12N2O2S
- 分子量
- 224.28
- 中文别名
- 化合物S 18986; 化合物 T16816; S 18986,AMPA受体的正变构调节剂; (3AS)-2,3,3A,4-四氢-1H-吡咯并[2,1-c][1,2,4]苯并噻二嗪5,5-二氧化物; S 18986; S-18986; S18986; S18986-1; S 18986-1; (S)-2,3-dihydro-(3,4)cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide; (+)-S-18986; (3AS)-2,3,3A,4-TETRAHYDRO-1H-PYRROLO(2,1-C)(1,2,4)BENZOTHIADIAZINE 5,5-DIOXIDE; 1H-PYRROLO(2,1-C)(1,2,4)BENZOTHIADIAZINE, 2,3,3A,4-TETRAHYDRO-, 5,5-DIOXIDE, (3AS)-; (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide; (3aS)-2,3,3a,4-Tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine-5,5-dioxide; (+)-(S)-2,3,3a,4-Tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine-5,5-dioxide; (3aS)-5,5Dioxo-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine; (S)-2,3,3a,4-Tetrahydro-1H-benzo[e]pyrrolo[2,1-c][1,2,4]thiadiazine 5,5-dioxide
- 用途
- 生命科学领域，作为选择性、口服活性、脑渗透性AMPA型受体正向变构调节剂，用于增强啮齿动物认知能力，激活大鼠海马去甲肾上腺素和乙酰胆碱释放，增强物体识别实验记忆；在中年啮齿动物空间记忆模型中显示抗遗忘特性，5-50 mg/kg腹腔注射（i.p.）可增强4和20次爆发性强直刺激诱发的增强效应。
