- 英文名称
- Phorbol 12-myristate 13-acetate
- 分子式
- C36H56O8
- 分子量
- 616.83
- 中文别名
- 乙酸佛波酯; 豆蔻酰佛波醇乙酯; 佛波酯; 12-十四酸酯13-乙酸佛波醇酯; 12-O-十四烷酰佛波醋酸酯-13; 12-豆蔻酸-13-乙酸佛波醇; (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-乙酰氧基-4a,7b-二羟基-3-(羟甲基)-1,1,6,8-四甲基-5-氧代-1a,1b,4,4a,5,7a,7b,8,9,9a-十氢-1H-环丙烷并[3,4]苯并[1,2-e]环戊并环庚烯-9-基 十四酸酯; 13-O-acetylphorbol 12-myristate; 12-O-Tetradecanoyl-Phorbol-13-Acetate; 12-O-tetradecanoyl phorbol-13-acetate; 4BETA-PHORBOL 12-MYRISTATE 13-ACETATE; 12-O-Tetradecanoylphorbol-13-acetate; 4β-Phorbol 12-myristate 13-acetate; Tetradecanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester; TPA; PMA; tetradecanoylphorbol acetate; (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-Acetoxy-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl myristate; 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate; phorbol 13-acetate 12-myristate
- 用途
- 作为促癌剂（TPA为活性最高的佛波酯），用于激活PKC信号通路，在体外研究中诱导THP-1细胞分化为巨噬细胞样表型，在体内研究中通过PKC途径保护线粒体功能；急性毒性测试中静脉注射小鼠LD50为0.309 mg/kg，可燃性危险特性为可燃，火场排出辛辣刺激烟雾，储运需库房通风低温干燥并与食品分开储运，灭火剂可选用水、砂土、泡沫。
