- 英文名称
- 4,5,13-Trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one
- 分子式
- C26H28N8O
- 分子量
- 468.55
- 中文别名
- 二氢-4,5,13-三甲基-2-[[1-(4-哌啶基)-1H-吡唑-4-基]氨基]-6H-萘并[2,3-e]嘧啶并[5,4-b][1,4]二氮杂卓-6-酮; HTH-01-015; 化合物HTH-01-015; 5,13-Dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one; HTH-01-015; HTH 01 015; HTH01015; HTH 01-015; HTH-01015; 4,5,13-trimethyl-2-{[1-(piperidin-4-yl)-1H-pyrazol-4-yl]amino}-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one; 2,7,9-trimethyl-5-[(1-piperidin-4-ylpyrazol-4-yl)amino]-2,4,6,9-tetrazatetracyclo[9.8.0.03,8.013,18]nonadeca-1(19),3,5,7,11,13,15,17-octaen-10-one
- 用途
- 化学合成；HTH-01-015 是一种选择性 NUAK1/ARK5 抑制剂 (IC50 为 100 nM)，抑制 NUAK1 的效力比抑制 NUAK2 高 100 倍以上 (IC50>10 μM)。
