- 英文名称
- (S)-7-Amino-N-(4-fluorobenzyl)-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(20),16,18-triene-20-carboxamide
- 分子式
- C24H34FN7O2
- 分子量
- 471.57
- 中文别名
- UNC2541; 化合物UNC2541; (7S)-7-氨基-N-[(4-氟苯基)甲基]-8-氧代-2,9,16,18,21-五氮杂双环[15.3.1]二十一烷-1(21),17,19-三烯-20-甲酰胺; (S)-7-氨基-N-(4-氟苄基)-8-氧代-2,9,16-三氮杂-1(2,4)-嘧啶杂环十六环十五甲酰胺; UNC2541; (7s)-7-Amino-N-[(4-Fluorophenyl)methyl]-8-Oxo-2,9,16,18,21-Pentaazabicyclo[15.3.1]henicosa-1(21),17,19-Triene-20-Carboxamide; (7S)-7-amino-N-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide; UNC-2541; UNC 2541; 2,9,16,18,21-Pentaazabicyclo[15.3.1]heneicosa-1(21),17,19-triene-20-carboxamide, 7-amino-N-[(4-fluorophenyl)methyl]-8-oxo-, (7S)-; (7S,16E)-7-amino-N-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(20),16,18-triene-20-carboxamide; (S)-7-amino-N-(4-fluorobenzyl)-8-oxo-2,9,16-triaza-1(2,4)-pyrimidinacyclohexadecaphane-15-carboxamide
- 用途
- 化学合成；作为有效Mer酪氨酸激酶（MerTK）特异性抑制剂，与MerTK ATP结合口袋结合，IC50值为4.4 nM，对Axl、Tyro3和Flt3选择性高，可抑制磷酸化的MerTK（EC50 510 nM）。
