- 英文名称
- Ponatinib-d8
- 分子式
- C29H19D8F3N6O
- 分子量
- 540.61
- 中文别名
- 纳替尼-D8; 泊那替尼杂质; [2H8]-PONATINIB; [2H8]-帕纳替尼; [2H8]-普纳替尼; 普纳替尼D8; [2H8]-Ponatinib; AP24534 D8; D8-Ponatinib; Ponatinib D8; 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((2,2,3,3,5,5,6,6-octadeutero-4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide; 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(2,2,3,3,5,5,6,6-octadeuterio-4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide; 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl-2,2,3,3,5,5,6,6-d8)methyl]-3-(trifluoromethyl)phenyl]-benzamide; 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(2,2,3,3,5,5,6,6-octadeuterio-4-methyl-piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide; 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)methyl)-3-(trifluoromethyl)phenyl)benzamide
- 用途
- 示踪分析试剂。纳替尼-D8（Ponatinib-d8）是Ponatinib的氘代物，Ponatinib是口服有效的多靶点激酶抑制剂，抑制Abl、PDGFRα、VEGFR2/KDR/Flk-1、FGFR1和Src的IC50分别为0.37 nM、1.1 nM、1.5 nM、2.2 nM和5.4 nM。
