- 英文名称
- N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
- 分子式
- C31H26F2N4O6
- 分子量
- 588.56
- 中文别名
- CEP-40783; N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]-3-氟苯基]-3-(4-氟苯基)-1,2,3,4-四氢-1-(1-甲基乙基)-2,4-二氧代-5-嘧啶甲酰胺; 化合物CEP40783; N-[4-[(6,7-二甲氧基喹啉-4-基)氧基]-3-氟苯基]-3-(4-氟苯基)-1-异丙基-2,4-二氧代-1,2,3,4-四氢嘧啶-5-甲酰胺; CEP-40783; CEP40783; RXDX-106; N-{4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl}-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide; 3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid [4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]amide; N-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide; 5-Pyrimidinecarboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-(1-methylethyl)-2,4-dioxo-; N-(4-((6,7-Dimethoxy-4-quinolinyl)oxy)-3-fluorophenyl)-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-(1-methylethyl)-2,4-dioxo-5-pyrimidinecarboxamide; N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-pyrimidine-5-carboxamide
- 用途
- 化学合成；作为口服有效的TAM（TYRO3, AXL, MER）/Met（c-Met）抑制剂，用于抑制TAM和c-MET磷酸化及下游信号通路，降低细胞活性，抑制肿瘤细胞增殖，影响肿瘤微环境以形成抗癌环境。
