- 英文名称
- (1S,2R)-2-((S)-1-((1,3-Dioxoisoindolin-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclohexane-1-carboxylic acid
- 分子式
- C26H26N2O5
- 分子量
- 446.5
- 中文别名
- ML334; 化合物ML334; 化合物T12078; (1S,2R)-2-((S)-1-((1,3-二氧代异吲哚啉-2-基)甲基)-1,2,3,4-四氢异喹啉-2-羰基)环己烷-1-甲酸; ML334; ML 334; LH601A; (1S,2R)-2-[(1S)-1-[(1,3-dioxoisoindol-2-yl)methyl]-3,4-dihydro-1H-isoquinoline-2-carbonyl]cyclohexane-1-carboxylic acid; (1S,2R)-2-[[(1S)-1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl]cyclohexanecarboxylic acid; (1S,2R)-2-((S)-1-((1,3-Dioxoisoindolin-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclohexanecarboxylic acid; (1S,2R)-2-[(1S)-1-[(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinoline-2(1H)-carbonyl]cyclohexane-1-carboxylic acid; (1S,2R)-2-[(1S)-1-[(1,3-dioxoisoindolin-2-yl)methyl]-3,4-dihydro-1H-isoquinoline-2-carbonyl]cyclohexanecarboxylic acid; (1S,2R)-2-[[(1S)-1-[(1,3-dioxo-2-isoindolyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-oxomethyl]-1-cyclohexanecarboxylic acid; ML-334; Keap1-nrf2 interaction probe, ml334; Cyclohexanecarboxylic acid, 2-[[(1S)-1-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl]-, (1S,2R)-
- 用途
- ML334（LH601A）是有效的细胞可渗透NRF2激活剂，通过抑制Keap1-NRF2蛋白质相互作用发挥作用，以Kd值1μM结合Keap1 Kelch域，刺激NRF2表达和核易位并诱导抗氧化反应元件（ARE）活性，在体外研究中（HEK293细胞，50-100μM，6-16小时）可增加NQO1和TRX1 mRNA表达，增强HO-1 mRNA和蛋白表达。
