- 英文名称
- PK-THPP
- 分子式
- C29H32N4O2
- 分子量
- 468.59
- 中文别名
- 化合物T24648; 化合物PK-THPP; pk-thpp; 1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one; 1-(1-(6-([1,1'-biphenyl]-4-carbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)piperidin-4-yl)butan-1-one; 1-{1-[6-(Biphenyl-4-carbonyl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-yl]-piperidin-4-yl}-butan-1-one; 1-[1-(6-{[1,1'-biphenyl]-4-carbonyl}-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-4-yl)piperidin-4-yl]butan-1-one; 1-[1-[6-(4-phenylbenzoyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl]butan-1-one; 1-(1-(6-(Biphenylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)piperidin-4-yl)butan-1-one; 1-[1-[6-([1,1′-Biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone; 1-[1-[6-(4-phenylbenzoyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]-4-piperidyl]butan-1-one; PKTHPP; PK THPP
- 用途
- PK-THPP 是一种有效的 TASK-3 离子通道阻滞剂(对于 TASK-3 和 TASK-1，IC50s 分别为 35 nM 和 300 nM)。PK-THPP 增加大鼠的呼吸频率并诱导呼吸性碱中毒。
