- 英文名称
- 3-Deazaneplanocin A
- 分子式
- C12H14N4O3
- 分子量
- 262.26
- 中文别名
- (1S,2R,5R)-5-(4-氨基-1H-咪唑并[4,5-c]吡啶-1-基)-3-羟甲基-3-环戊烯-1,2-二醇; 3-去氮腺嘌呤; (1S,2R,5R)-5-(4-氨基-1H-咪唑并[4,5-c]吡啶-1-基)-3-(羟甲基)环戊-3-烯-1,2-二醇; (1S,2R,5R)-5-(4-氨基-1H-咪唑并[4,5-c]吡啶-1-基)-3-(羟基甲基)-3-环戊烯-1,2-二醇; 3-deazaneplanocin; DZNep; 3-Deaza-neplanocin; c^Neplanocin A; (1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol; 3-Cyclopentene-1,2-diol,5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, (1S,2R,5R)-; (1R,4R,5S)-4-(5-amino-4,7,9-triazabicyclo[4.3.0]nona-2,4,7,10-tetraen-9-yl)-2-(hydroxymethyl)cyclopent-2-ene-1,5-diol; 3-Deazaneplanocin-A; (-)-1-[(1R,4R,5S)-3-(Hydroxymethyl)-4,5-dihydroxy-2-cyclopenten-1-yl]4-aminoimidazo[4,5-c]pyridine
- 用途
- 3-Deazaneplanocin A（即(1S,2R,5R)-5-(4-氨基-1H-咪唑并[4,5-c]吡啶-1-基)-3-(羟甲基)环戊-3-烯-1,2-二醇）是有效的组蛋白甲基转移酶EZH2抑制剂和S-腺苷同型半胱氨酸水解酶AHCY抑制剂；体外可抑制OCI-AML3、HL-60、NSCLC等细胞增殖，体内可延长NOD/SCID小鼠白血病生存期，降低体重增长速率。
