- 英文名称
- Aureobasidin A
- 分子式
- C60H92N8O11
- 分子量
- 1101.42
- 中文别名
- 短梗霉素A; 金担子素A; 巴西分净; 巴西芬净A; (3S,6S,9S,12S,15R,18S,21S,24S,29aS)-21,24-二苄基-3,15-二((R)-仲丁基)-12-(2-羟基丙-2-基)-9-异丁基-6,18-二异丙基-5,11,17,23-四甲基十八氢-1H,15H-吡咯并[1,2-m][1]氧杂[4,7,10,13,16,19,22,25]八氮杂环二十七烷-1,4,7,10,13,16,19,22,25-九酮; Basifungin; aurantoside B; LY295337; LY-295337; NK 204; R106-1; NK-204; R106 1; Basifungina; Basifungine; R-106-1; basifunginum; Antibiotic R106I; AbA; Cyclo[L-Phe-N-methyl-L-Phe-L-Pro-L-aIle-N-methyl-L-Val-L-Leu-N-methyl-β-hydroxy-L-Val-[(3R)-D-Hmp-]-N-methyl-L-Val-]; Aureobasidin A (9CI); Aureobasidin A (AbA); Cyclo[L-alloisoleucyl-N-methyl-L-valyl-L-leucyl-N,3-dimethyl-L-threonyl-(2R,3R)-2-hydroxy-3-methylpentanoyl-N-methyl-L-valyl-L-phenylalanyl-N-methyl-L-phenylalanyl-L-prolyl]; (3S,6S,9S,12S,15R,18S,21S,24S,29aS)-21,24-Dibenzyl-3,15-di((R)-sec-butyl)-12-(2-hydroxypropan-2-yl)-9-isobutyl-6,18-diisopropyl-5,11,17,23-tetramethyloctadecahydro-1H,15H-pyrrolo[1,2-m][1]oxa[4,7,10,13,16,19,22,25]octaazacycloheptacosine-1,4,7,10,13,16,19,22,25-nonaone
- 用途
- 作为抗真菌药物，用于抑制丝状真菌（如Aureobasidium pullulans、Candida glabrata等）生长，通过抑制肌醇磷酸化神经酰胺合成酶活性干扰鞘脂合成，不破坏DNA、RNA和蛋白质合成；聚乙二醇修饰的巴西芬净可增强溶解能力、延长半衰期，用于提高治疗效果。
