- 英文名称
- Tubastatin A
- 分子式
- C20H21N3O2
- 分子量
- 335.4
- 中文别名
- Tubastatin A; TUBASTATIN-A游离态; TUBASTATIN A 游离; 化合物TUBASTATIN A; 抑制剂Tubastatin A; N-Hydroxy-4-((2-methyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)methyl)benzamide; Tubastatin-A; N-hydroxy-4-[(2-methyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide; N-hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)benzamide; N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide; Benzamide, N-hydroxy-4-((1,2,3,4-tetrahydro-2-methyl-5H-pyrido(4,3-b)indol-5-yl)methyl)-; N-Hydroxy-4-((1,2,3,4-tetrahydro-2-methyl-5H-pyrido(4,3-b)indol-5-yl)methyl)benzamide; N-hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl)benzamide; Benzamide, N-hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]-; Tubastatin A (free base); Tubastatin A BASE; N-hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)methyl)benzamide; Tubastatin A(free base); 4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzenecarbohydroxamic acid
- 用途
- 化学合成；作为有效的选择性HDAC6抑制剂，用于抑制胆管癌生长、抗炎、抗关节炎等生物活性研究；体外研究中用于诱导α-tubulin乙酰化、抑制细胞死亡、调节Hh和MAPK信号通路；体内研究中用于降低肿瘤重量、抑制炎症模型中的炎症反应。
