- 英文名称
- Celgosivir
- 分子式
- C12H21NO5
- 分子量
- 259.3
- 中文别名
- (1S,6S,7S,8R,8aR)-1,7,8-三羟基八氢吲哚嗪-6-基 丁酸酯; 化合物 T10755L; (1S,6S,7S,8R,8aR)-1,7,8-Trihydroxyoctahydroindolizin-6-yl butyrate; [(1S,6S,7S,8R,8aR)-1,7,8-trihydroxy-1,2,3,5,6,7,8,8a-octahydroindolizin-6-yl] butanoate; 6-O-butanoylcastanospermine; BuCast; (1S,6S,7S,8R,8aR)-1,7,8-Trihydroxyoctahydro-6-indolizinyl butyrate; MX-3253; 6-O-Butanoyltanospermine; Butanoic Acid (1S,6S,7S,8R,8aR)-Octahydro-1,7,8-trihydroxy-6-indolizinyl Ester; MDL 28574; 6-O-butyryltanospermine; Butanoic acid, (1S,6S,7S,8R,8aR)-octahydro-1,7,8-trihydroxy-6-indolizinyl ester; MDL-28574; MBI-3253; celgosivirum; 6-O-Butyrylcastanospermine; 6-Butyryl castanospermine; Castanospermine 6-butyrate; (1S)-1,2,3,5,6,7,8,8aα-Octahydro-6α-butyryloxyindolizine-1β,7β,8α-triol
- 用途
- 生命科学领域，作为α-葡萄糖苷酶I抑制剂，用于体外抑制α-葡萄糖苷酶I（IC50=1.27 μM），在HIV感染细胞中积累糖基化寡糖，抑制HIV-1（IC50=2.0±2.3 μM）、BVDV（IC50=16 μM和47 μM）、DENV2（EC50=0.2 μM）等病毒复制；体内用于保护AG129小鼠免受登革病毒感染，剂量50 mg/kg BID给药5天有效，可快速代谢为castanospermine。
