- 英文名称
- TM-N1324
- 分子式
- C18H13ClFN7O
- 分子量
- 397.79
- 中文别名
- TM-N1324; 化合物T17103; 4-(2-Chloro-4-fluorophenyl)-3-methyl-1-(1H-purin-6-yl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one; 4-(2-Chloro-4-fluorophenyl)-1,4,5,7-tetrahydro-3-methyl-1-(9H-purin-6-yl)-6H-pyrazolo[3,4-b]pyridin-6-one; 6H-Pyrazolo[3,4-b]pyridin-6-one, 4-(2-chloro-4-fluorophenyl)-1,4,5,7-tetrahydro-3-methyl-1-(9H-purin-6-yl)-; 4-(2-chloro-fluorophenyl)-3-methyl-1-(9H-purin-6-yl)-1H,4H,5H,6H,7H-pyrazolo[3,4-b]pyridin-6-one; TM-N-1324; TM N1324; TMN1324; Tm-n1324; 4-(2-chloro-4-fluorophenyl)-3-methyl-1-(9H-purin-6-yl)-4,5-dihydro-1H-pyrazolo[3,4-b]pyridin-6-ol; 4-(2-chloro-4-fluorophenyl)-3-methyl-1-(9H-purin-6-yl)-4,5-dihydro-1H-pyrazolo[3,4-b]pyridin-6(7H)-one; 4-(2-chloro-4-fluoro-phenyl)-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one; 4-(2-Chloro-4-fluorophenyl)-3-methyl-1-(7H-purin-6-yl)-4,5-dihydro-1H-pyrazolo[3,4-b]pyridin-6(7H)-one; 4-(2-chloro-4-fluorophenyl)-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
- 用途
- 化学合成；作为G蛋白偶联受体39（GPR39）的激动剂，在Zn²⁺存在下对人和鼠GPR39的EC50值分别为9 nM和5 nM，无Zn²⁺时分别为280 nM和180 nM；体外研究显示其对GPR39激活效能高，且ADME性质良好，在pH 7.0时水溶性65 μM，能增加生长抑素释放53%。
