- 生物活性
Salinomycin sodium salt (Salinomycin sodium)，一种钾离子载体抗生素，是 Wnt/β-catenin 信号传导的有效抑制剂。Salinomycin sodium salt (Salinomycin sodium) 作用于 Wnt/Fzd/LRP 复合物，阻断 Wnt 诱导的 LRP6 磷酸化，导致 LRP6 蛋白降解。Salinomycin sodium salt (Salinomycin sodium) 选择性抑制人肿瘤干细胞。
- 靶点
Wnt/β-catenin
- 体外研究
Salinomycin (0.1-8 µM) inhibits the growth of HUVECs in a dose-dependent manner, accounting for 32.1 and 59.2% inhibition at 4 and 8 µM, respectively. HUVECs exposed to 2, 4 and 8 µM of Salinomycin for 48 h show a dose-dependent reduction in cell number and a change in cell morphology. Salinomycin (4 µM) treatment effectively inhibits HUVEC migration and invasion, and significantly disrupt the capillary-like tube formation of HUVECs. Salinomycin significantly suppresses the expression levels of phosphorylated (p)-FAK in a time- and dose-dependent manner in HUVECs. Salinomycin inhibits HUVEC angiogenesis by disturbing the VEGF-VEGFR2-AKT signaling axis. Combination of RSVL and Salinomycin synergistically inhibits the proliferation of TNBC (MDA-MB-231) cells. RSVL and Salinomycin effectively reduce wound healing, colony and tumorosphere forming capability in TNBC cells. Synergistic combination of RSVL and Salinomycin induces apoptosis in both culture conditions by significant upregulation of Bax with decreased Bcl-2 expression as comparison to untreated and alone drug treatments. Salinomycin (0, 2, 4, 8 and 16 μM) significantly inhibits the proliferation of A2780 and SK-OV-3 cell lines in a dose- and time-dependent manner, (IC
50 24h
: 13.8 μM, IC
50 48h
: 6.888 μM and IC
50 72h
: 4.382 μM for A2780 cell lines), (IC
50 24h
: 12.7 μM, IC
50 48h
: 9.869 μM and IC
50 72h
: 5.022 μM for SK-OV-3 cell lines). Salinomycin blocks the Wnt/β-catenin pathway in EOC cells. Salinomycin (2 μM) reduces cancer cell proliferation, inhibits STAT3 phosphorylation and P38 and β-catenin expressions, and suppresses epithelial-mesenchymal transition in colorectal cancer cells. Salinomycin (1-5 μM) inhibits cancer cell proliferation and STAT3 signaling in colorectal cancer cells. Furthermore, Salinomycin activates Akt (Ser 473) and down-regulates Hsp27 (Ser 82) phosphorylation in HT-29 and SW480. Salinomycin down-regulates hTERT and reduces telomerase activity when combined with telomerase inhibitor.
- 体内研究
Salinomycin (5 and 10 mg/kg) significantly supresses the average tumor volume and tumor weight. Salinomycin hinders the U251 human glioma cell growth in vivo via inhibition of angiogenesis with involvement of AKT and FAK dephosphorylation. Salinomycin (0.5 mg/kg b.wt.) enhances the mean survival time of the tumor bearing Swiss albino mice.
- 化学性质
白色或淡黄色结晶性粉末，微有特异臭，熔点140-142℃。易溶于丙酮、三氯甲烷、苯、乙酸乙酯、乙醚和甲醇，几乎不溶于水。大白鼠经口LD
50
70-100mg/kg，小白鼠经口LD
50
50mg/kg，鸡LD
50
150mg/kg。
- 盐霉素钠是安全有效的抗球虫药，对大多数革兰阳性菌也有抑制作用，对鸡的球虫、柔嫩艾氏、毒害艾氏、巨型艾氏、堆形艾氏和哈氏球虫均有效。可用于鸡饲料，用量为50-60g/t，产蛋期禁用，停药期5天。马属动物忌用，用后会致死；禁止与泰妙菌素、竹桃霉素同时使用。
直接绿 89; Anardirect Green 6NB; Best Direct Fast Green BNB; Dinamine Green B NBH; Kemanarect Green BBD; Pidictive Green; Vicorect Green 89; Direct Green 2BNB
用途
- 化学性质
灰色粉末。溶于水、丙酮、乙二醇乙醚，微溶于乙醇，不溶于其他有机溶剂。
- 直接墨绿 NB 可用于代替直接墨绿 B。主要用于棉、黏胶纤维、蚕丝及其织物的染色和印花，也用于黏锦、毛黏混纺织物的染色。
直接黑D; 直接黑17; C.I.直接黑17; 直接绸灰; 直接大刀灰; 6-氨基-3-[2-[4-[2-(4-氨基苯基)偶氮基]-2-甲氧基-5-甲基苯基]偶氮基]-4-羟基-2-萘磺酸钠盐; Direct Black 17; sodium 6-amino-3-[[4-[(4-aminophenyl)azo]-4-methoxy-m-tolyl]azo]-4-hydroxynaphthalene-2-sulphonate; Benzo Black DS; Azogen Black D; Direct Grey 6BR; Grey D
用途
- 化学性质
黑色粉末。水溶性一般，其水溶液呈紫黑色，加浓盐酸产生深棕色沉淀，加浓碱产生灰紫色沉淀。溶于乙醇呈灰光紫色。于浓硫酸中呈深蓝光绿色，稀释后产生紫棕色沉淀。
- 直接灰 D 广泛用于棉、黏胶纤维织物的染色，也用于蚕丝织物的染色和印花，得青红光灰至绿光黑色，色泽深浓，匀净。还可与黄、红、蓝、棕等染料拼色。染色后常用固色剂 Y 或固色剂 M 处理以及进行脲醛树脂整理。还可用于维纶织物染色。
- 主要用于棉、麻、粘胶等纤维素纤维织物的染色，也可用于蚕丝、锦纶及其混纺织物的染色，还可作粘胶及蚕丝织物的印花用。本品染棉、粘胶织物后，通常采用固色剂Y或固色剂M处理，以及进行脲醛树脂整理。经固色剂Y处理，色光呈微红；经固色剂M处理，色光转暗，经脲醛树脂整理，色光基本不变。
- 主要用于棉、麻、粘胶等织物的染色
直接红12B; 直接桃红12B; 7,7'-iminobis[4-hydroxy-3-(phenylazo)-2-naphthalenesulfonic aci disodium sa; Benzo Rhoduline Red B; C.I. Direct red 31; C.I.Direct Red 31(29100); Chloramine Rose B,Pyrazol Pink 2B; Diphenyl Red RW; Direct pink; Nippon Fast Red 2B; Disodium 7,7'-iminobis{4-hydroxy-3-[(E)-phenyldiazenyl]-2-naphthalenesulfonate}; Disodium 7,7'-iminobis(4-hydroxy-3-(phenylazo)naphthalene-2-sulphonate); 2-Naphthalenesulfonic acid, 7,7'-iminobis[4-hydroxy-3-[(E)-2-phenyldiazenyl]-, sodium salt (1:2)
天狼星玫红,BB; 5,5'-[羟基双[亚氨(2-磺基-4,1-亚苯基)偶氮]]双(6-氨基-4-羟基)-2-萘磺酸四钠; 天狼星红BB; 天狼星红; 天狼猩红BB; 氯唑耐晒桃红; CI 25380; CI NO 25380; DIRECT RED 75 (C.I. 25380); SIRIUS ROSE BB, FOR MICROSCOPY; Direct Fast Pink BK; Vital New Red (C.I. 25380); Aizen Primula Pink 2BLH special; tetrasodium 5,5'-[carbonylbis[imino(2-sulphonato-4,1-phenylene)azo]]bis(6-amino-4-hydroxynaphthalene-2-sulphonate); Chlorazol fast pink; Vital New Red; C.I. Direct Red 75; Solar Rubine CB; Aizen Primula Pink 2BLH; Direct Fast Pink B; Benzo Fast Pink 2BL; Chlorazol Fast Pink BK
用途
- 化学性质
棕色粉末。水溶性好，微溶于乙二醇乙醚、乙醇，不溶于其他有机溶剂。其水溶液呈品红色，加入浓盐酸产生紫色沉淀，加烧碱产生红色沉淀。于浓硫酸中呈灰光蓝色，稀释后呈紫色；于浓硝酸中部分溶解呈黑色。染色时遇铜、铁离子色光稍有变化。
- 直接耐晒桃红 BK 用于棉、黏胶纤维织物的染色和直接印花，得粉红色。具有良好的匀染性和移染性，上染率一般。染色后常用固色剂 Y 处理，以提高湿牢度，但色光稍蓝。也用于蚕丝、羊毛、锦纶织物的染色和印花以及与分散染料同浴高温染涤黏混纺织物。
C.I.直接红81; 氯冉亭坚牢红5B; 直接耐晒红4B; 氯冉亭坚牢红; 直接红81 [CI 28160]; 直接红 4B; 直接耐晒大红 4B; CHLORANTINE FAST RED 5B; disodium 7-benzamido-4-hydroxy-3-[[4-[(4-sulphonatophenyl)azo]phenyl]azo]naphthalene-2-sulfonate; SOLARREDBA; 7-Benzoylamino-4-hydroxy-3-[4-(4-sulfo-phenylazo)-phenylazo]-naphthalin-2-sulfonsaeure,Dinatrium-Salz; saturnredb; Chlorantinlichtrot-5BL; Red 4BL; siriusred4b; 7-benzoylamino-4-hydroxy-3-[4-(4-sulfo-phenylazo)-phenylazo]-naphthalene-2-sulfonic acid,disodium-salt; C. I. Direct Red 81; DURAZOL RED; solarredb; helionred8b; SiruisRed4B; CALCODUR RED 8BL; CHLORANTINE FAST RED; CHLOROANTINE FAST RED 5B
Direct Brown 112; C.I. Direct Brown 112; Direct Bordeaux 4GM; Direct Light Brown 8R; Helion Brown 8RLL; Tertrodirect Light Brown 8R; Triamin Brown 8RLL
直接耐晒橙D-GL; 直接耐晒橙GGS; Sirius Supra Oange GGL; Solophenyl Orange TRL; Cuprofix(Sloar)Orange 2GL; Pyrazol Fast Orange 2GLL; Best Direct Supra Orange 2GL; Kayafect Orange G
直接耐晒灰2BL; C.I.Direct Black 103; Diazol Light Grey 4B; 3-[[4-[[4-[(7-Amino-1-hydroxy-3-sodiosulfo-2-naphthalenyl)azo]-6-sodiosulfo-1-naphthalenyl]azo]-1-naphthalenyl]azo]naphthalene-1,5-disulfonic acid disodium salt; Direct Fast Black 2B; Direct Fast Grey L; Direct Grey Light Fast
直接黑19; 4-氨基-3,6-双[[4-[(2,4-二氨基苯基)偶氮]苯基]偶氮]-5-羟基萘-2,7-二磺酸二钠盐; 直接耐晒墨 L-3BG; 直接黑 G; 直耐晒黑G; 4-氨基-3,6-双((4-((2,4-二氨基苯基)二氮烯基)苯基)二氮烯基)-5-羟基萘-2,7-二磺酸钠盐; Direct black RN; disodium 4-amino-3,6-bis[[4-[(2,4-diaminophenyl)azo]phenyl]azo]-5-hydroxynaphthalene-2,7-disulphonate; Black G; Atul Direct Black VG; Benzo Fast Black G; Condires Black AN; Kayarus Black G; Sumilight Black G; Vicorect Black FB.; RIFAZOLBLACKGR; 2,7-Naphthalenedisulfonic acid, 4-amino-3,6-bis[(E)-2-[4-[(E)-2-(2,4-diaminophenyl)diazenyl]phenyl]diazenyl]-5-hydroxy-, sodium salt (1:2); Disodium 4-amino-3,6-bis[(E)-{4-[(E)-(2,4-diaminophenyl)diazenyl]phenyl}diazenyl]-5-hydroxy-2,7-naphthalenedisulfonate
用途
- 简介
直接黑19是黑色粉末。水溶性很好，其水溶液呈绿光黑色，加入浓碱液呈绿光蓝色，加入10％硫酸颜色略显红。微溶于乙醇、丙酮。于浓硝酸中呈深棕色，于浓硫酸中呈绿光黑色，稀释后产生红光黑色沉淀。染色时遇铜离子色光微绿，遇铁离子色光略有变化。
- 化学性质
黑色粉末。水溶性很好，其水溶液呈绿光黑色，加入 10%硫酸颜色略显红；加入浓碱液呈绿光蓝色。微溶于乙醇、丙酮。于浓硫酸中呈绿光黑色，稀释后产生红光黑色沉淀；于浓硝酸中呈深棕色。染色时遇铜离子色光微绿，遇铁离子色光略有变化。
- 直接耐晒黑 G 是主要的黑色染料品种之一。主要用于棉、黏胶纤维以及棉、黏胶纤维与蚕丝、羊毛交织、混纺织物的染色和直接印花。主要染黑色，印花则普遍采用灰及黑色，也可与棕色染料拼成各种不同深度的咖啡等色，少量用于调色光，以增加色谱。染羊毛黏胶纤维混纺织物时，可与中性黑 BRL 同浴染色，得色均匀。也可与分散染料同浴染涤黏混纺织物。上染率好，移染性稍差，染色后可用固色剂 Y、固色剂 M 处理，但色光微绿，用脲醛树脂整理可不改变色光，也能提高湿处理牢度。
直接耐晒蓝 3RL; C.I.直接蓝 67; Atul Direct Supra Light Fast Blue 3R; Dyrect Fast Blue 4RD; Helion Blue 3RL; Saturn Blue L3R; Solar Brilliant Blue A; Triamin Blue 3RL.; C.I.DirectBlue67
二氨基蓝 BB; 直接蓝2B; 直接靛蓝; 直接靛蓝2B; 直接青蓝2B; 直接兰6; 直接蓝2R; direct blue; C.I. Direct Blue 6, tetrasodium salt; Diaminreinblau; Benzo Blue 2B; Nippon Blue B; LIGHT BLUE; direct sky blue 5B; PONTAMINE BLUE BB; tetrasodium 3,3'-[[1,1'-biphenyl]-4,4'-diylbis(azo)]bis[5-amino-4-hydroxynaphthalene-2,7-disulphonate]
直接铜盐蓝BR; C.I.直接蓝168; Direct Blue 168; Direct Copper Blue BR; Japanol Copper Blue 2B; Kayaku direct copper blue 2B; Mitsui Direct Copper Blue 2B; Copper Blue 2B
