- 英文名称
- Escin IIa
- 分子式
- C54H84O23
- 分子量
- 1101.24
- 中文别名
- 七叶皂苷IIA; AESCIN IIA; EscinIC; Escin-IIa; Escin iia; (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→4)-O-[β-D-xylopyranosyl-(1→2)]-β-D-Glucopyranosiduronic acid; (2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8R,8aR,9R,10R,12aS,14aR,14bR)-9-acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(E)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxane-2-carboxylic acid; (3β,16α,21β,22α)-22-Acetoxy-16,24,28-trihydroxy-21-{[(2E)-2-methyl-2-butenoyl]oxy}olean-12-en-3-yl β-D-glucopyranosyl-(1->4)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosiduronic acid
- 用途
- 生命科学领域，对动物急性炎症有积极作用；作为中草药成分，对乙醇诱导的胃粘膜损伤有明显的保护作用。体内研究表明，七叶皂苷C（Escin IIa）在10-50 mg/kg剂量下经口服给药，能有效抑制大鼠乙醇诱导的胃粘膜损伤，且在50-200 mg/kg剂量范围内对醋酸、组胺、血清素诱导的血管通透性增加及角叉菜胶诱导的大鼠爪部水肿有抑制作用。
