18877-64-0 棕榈酰-L-肉碱盐酸盐

常温运输。危险性质：非危险化学品。GHS分类：皮肤刺激类别2（H315）、严重眼刺激类别2（H319）、呼吸道刺激类别3（H335）。WGK Germany:3，F:3-10，海关编码2923900090，存储类别11 - 可燃固体。防护措施：P261、P264、P264+P265、P271、P280、P302+P352、P304+P340、P305+P351+P338、P319、P321、P332+P317、P337+P317、P362+P364、P403+P233、P405、P501。

L-Palmitoylcarnitine chloride is a long-chain acylcarnitine and fatty acid metabolite, which accumulates in the sarcolemma during ischemia and disrupts the membrane lipid environment. It inhibits KATP channel activity by interacting with Kir6.2 without affecting single-channel conductance, and simultaneously enhances the ATP sensitivity of the channel (IC50 decreased from 62 to 30 µM). The modulation of the membrane lipid environment caused by it mainly alters KATP channel function through interaction with the endogenous PI cascade, especially PIP2.

生命科学