化学合成。
化学合成
合成路线 1（1. 合成：1219741-79-3）
产率：90%
合成条件：With N-iodo-succinimide In acetic acid at 25℃; for 1.50 h;
实验步骤：向4-溴-3-氟 - 苯胺（40.0g，211.6mmol）的乙酸（520mL）溶液中缓慢加入25℃的N-碘琥珀酰亚胺（57.14g，253.9mmol）。搅拌混合物。 将反应混合物倒入冰水中并过滤。剩余物在真空中干燥，得到4-溴-5-氟-2-碘 - 苯胺，为棕色固体（60g，90％）。
参考文献：
- [1] Patent: US2012/252853, 2012, A1. Location in patent: Page/Page column 25 [2] Patent: US9212182, 2015, B2. Location in patent: Page/Page column 222 [3] Patent: WO2014/202580, 2014, A1. Location in patent: Page/Page column 98 [4] Patent: US2010/81643, 2010, A1. Location in patent: Page/Page column 125 [5] Patent: WO2012/103806, 2012, A1. Location in patent: Page/Page column 39 [6] Patent: US2015/183802, 2015, A1. Location in patent: Paragraph 1006-1009 [7] Patent: WO2015/102929, 2015, A1. Location in patent: Page/Page column 120 [8] Patent: WO2017/153952, 2017, A1. Location in patent: Page/Page column 176
