化学合成。
化学合成
合成路线 1（1. 合成：337915-79-4）
产率：93%
合成条件：With zinc In methanol; water at 20℃; for 1 h;
实验步骤：将12a（350mg，1.51mmol），锌（495mg，7.57mmol）和NH 4 Cl（810mg，15.15mmol）在MeOH（4mL）/水（2mL）中的溶液在室温下搅拌1小时。 通过过滤除去不溶物质并中和饱和NaHCO 3溶液。 浓缩混合物并用EtOAc萃取。 分离有机层，用水和盐水洗涤，经MgSO 4干燥，真空浓缩，得到标题化合物，为棕色固体（282mg，93％）。 1H NMR（400MHz，DMSO-d6）δ2.68（3H，d，J = 4.9Hz），4.60（2H，s），4.87（1H，d，J = 4.9Hz），6.32-6.58（3H，m）。 MS（ESI / APCI）m / z = 202.09 [M + H] +。
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