化学合成。
化学合成
合成路线 1（1. 合成：947248-68-2）
产率：99%
合成条件：With hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine In methanol; ethanol at 20 - 70℃; for 5 h;
实验步骤：步骤b）形成6-溴[1,2,4]三唑并[1,5-a]吡啶-2-胺A {[（5-溴吡啶-2-基）氨基]硫代碳酰基}氨基甲酸乙酯的悬浮液（12.3） 将g，40.4mmol），盐酸羟胺（14.1g，202mmol）和DIEA（15.7g，122mmol）在MeOH和EtOH的混合物（比例1：1,200mL）中在室温下搅拌2小时，然后 在70℃下保持3小时。 减压除去溶剂。 将残余物溶于二恶烷/水（1：1）中并过滤，得到标题化合物，为灰白色粉末（42.6g，99％）。 HPLC，Rt：1.1分钟（纯度99.8％）。 LC / MS，M +（ESI）：215.3。
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