化学合成。
化学合成
合成路线 1（1. 合成：163444-17-5）
产率：97%
合成条件：With Iodine monochloride In methanol; dichloromethane at 0 - 20℃;
实验步骤：步骤2 2-碘-4-（三氟甲基）苯胺向500mL三颈圆底烧瓶中加入4-（三氟甲基）苯胺（22.5g，0.14mol）和MeOH（100mL）。 在0℃下向上述溶液中滴加IC1（25g，0.15mol）在CH 2 Cl 2（100mL）中的溶液。将得到的混合物在室温下搅拌1小时。 通过TLC监测反应进程（EtOAc /石油醚= 1：10，R f = 0.5）。 后处理：将混合物真空浓缩。 将残余物重新溶解在CH 2 Cl 2中，用水洗涤，用无水Na 2 SO 4干燥并真空浓缩，得到37.8g（97％）产物。 1H NMR（300MHz，CDCl3）δ：7.86（d，J = 1.2Hz，1H），7.36（dd，J = 8.4,1.8Hz，1H），6.73（d，J = 8.7Hz，1H），4.41（ br，2H）。
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