化学合成。
化学合成
合成路线 1（1. 合成：19718-49-1）
产率：100%
合成条件：With N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate In methanol; dichloromethaneHeating / reflux
实验步骤：4-二氨基苯甲酸甲酯（5.0克; 0.033摩尔），二氯碘酸苄基三甲基铵（22.1克; 0.056摩尔）和碳酸钙（5.0克; 0.050摩尔）在二氯甲烷（200毫升）和甲醇（100克）的混合物中的溶液 搅拌并搅拌加热过夜。 将溶液冷却，用饱和硫酸氢钠洗涤，干燥并蒸发，得到所需产物（9.6g;定量），其不经进一步纯化直接用于EPO。 1 H NMR（400MHz，DMSOd 6）δppm3.75（s，3H）6.09（s，2H）6.75（d，J = 8.59Hz，1H）7.66（dd，J = 8.59,2.02Hz，1H ）8.11（d，J = 2.02Hz，1H）。
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