897671-69-1 N-[1,1'-联苯-4-基]-9,9-二甲基-9H-芴-2-胺

中文名称: N-[1,1'-联苯-4-基]-9,9-二甲基-9H-芴-2-胺
英文名称: N-([1,1'-Biphenyl]-4-yl)-9,9-dimethyl-9H-fluoren-2-amine
CAS号

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名称和标识

中文名: N-[1,1'-联苯-4-基]-9,9-二甲基-9H-芴-2-胺
英文名: N-([1,1'-Biphenyl]-4-yl)-9,9-dimethyl-9H-fluoren-2-amine
CAS号: 897671-69-1
分子式: C27H23N
分子量: 361.48
中文别名: 2-(4-联苯基)氨基-9,9-二甲基芴; N-(联苯-4-基)-9,9-二甲基-9H-芴-2-胺; N-([1,1'-联苯]-4-基)-9,9-二甲基-9H-芴-2-胺; N-([1,1'-二苯基]-4-基)-9,9-二甲基-9H-芴-2-胺; N-(4-联苯基)-(9,9-二甲基芴基)胺; N-(4-联苯)-9,9-二甲基芴胺; N-(4-[1,1'联苯基])-9,9-二甲基-9H-芴-2-胺; 9,9-二甲基-2-(4-联苯)芴胺; 9,9-二甲基-2-(4-氨基联苯)芴胺
英文别名: 9,9-dimethyl-N-(4-phenylphenyl)fluoren-2-amine; 9H-Fluoren-2-amine, N-[1,1'-biphenyl]-4-yl-9,9-dimethyl; 9,9-diMethyl-N-(4-phenylphenyl)-9H-fluoren-2-aMine; BADMF; N-(4-biphenyl)-(9,9-diMethylfluorene-2-yl)AMine; N-(bipheny-4-yl)-9,9-diMethyl-9H-fluoren-2-aMine; DMFNB; N-(4-Biphenylyl)-9,9-dimethyl-9H-fluoren-2-amine; N-(4-biphenyl)-(9,9-dimethylfluoren-2--yl)Amine

物化属性

LogP: 8.01
PSA: 12.03000
储存条件: 室温，干燥，密封
外观: 白色至类白色结晶或粉末
密度: 1.1±0.1 g/cm3
折射率

安全信息

安全说明

运输信息：常温运输。危险描述：非危险化学品，海关编码2921490090

生产及用途

用途与制备

N-[1,1'-联苯-4-基]-9,9-二甲基-9H-芴-2-胺为联苯胺的N取代衍生物，在医药、化工中间体的制备中广泛应用，也用于化学合成。

医药; 化工中间体

合成路线 1（1. 合成：897671-69-1）

产率：91% 合成条件：With palladium diacetate; caesium carbonate In toluene for 24 h; Reflux 实验步骤：反应器中的2L 50.0g联苯-4-胺（330mmol），2-溴-9,9-二甲基-9H-芴43.2g（276mmol），乙酸钯，1.2g（5.6mmol），膦胺，6.4g（11.02mmol），126g（386mmol）碳酸铯加入1000mL甲苯中，在回流下搅拌24小时。通过冷却至室温完成反应后，过滤并用甲苯在减压下浓缩。用柱色谱法分离，得到57g（收率91％） 参考文献：[1] Patent: KR2015/130797, 2015, A. Location in patent: Paragraph 0453-0458 [2] Patent: KR2015/114636, 2015, A. Location in patent: Paragraph 0546-0551 [3] Patent: CN107686484, 2018, A. Location in patent: Paragraph 0085-0088 [4] Patent: KR2016/78765, 2016, A. Location in patent: Paragraph 0187; 0190; 0195; 0196 [5] Patent: US2017/125688, 2017, A1. Location in patent: Paragraph 0314-0316 [6] Patent: KR2017/90390, 2017, A. Location in patent: Paragraph 0125; 0179-0182 [7] Patent: KR101763838, 2017, B1. Location in patent: Paragraph 0107; 0151-0154 [8] Patent: KR101531614, 2015, B1. Location in patent: Paragraph 0822-0825 [9] Patent: KR101486562, 2015, B1. Location in patent: Paragraph 0829-0833 [10] Patent: US2017/125677, 2017, A1. Location in patent: Paragraph 0113-0116 [11] Patent: US2017/125678, 2017, A1. Location in patent: Paragraph 0088; 0089; 0090; 0091 [12] Patent: KR101653337, 2016, B1. Location in patent: Paragraph 0194-0196 [13] Patent: KR2018/14985, 2018, A. Location in patent: Paragraph 0614; 0631-0637 [14] Patent: KR2015/100825, 2015, A. Location in patent: Paragraph 0191-0193 [15] Patent: KR2016/27985, 2016, A. Location in patent: Paragraph 0153-0155 [16] Patent: US2018/282295, 2018, A1. Location in patent: Paragraph 0149; 0150 [17] Patent: CN106928237, 2017, A. Location in patent: Paragraph 0152; 0153-01551; 0260-0262 [18] Patent: CN106588674, 2017, A. Location in patent: Paragraph 0056; 0057; 0058 [19] Patent: WO2012/15265, 2012, A1. Location in patent: Page/Page column 14 [20] Patent: CN105153031, 2018, B. Location in patent: Paragraph 0083; 0084; 0085 [21] Patent: KR2018/47313, 2018, A. Location in patent: Paragraph 0172-0175 [22] Patent: KR2018/60582, 2018, A. Location in patent: Paragraph 0215-0217 [23] Patent: KR2018/60089, 2018, A. Location in patent: Paragraph 0165-0168 [24] Patent: KR2018/74172, 2018, A. Location in patent: Paragraph 0245-0248 [25] Patent: CN105111143, 2018, B. Location in patent: Paragraph 0084; 0085; 0086

897671-69-1 N-[1,1'-联苯-4-基]-9,9-二甲基-9H-芴-2-胺 - 化工 AI 网